The Value of NOTCH2NLC Gene Detection and Skin Biopsy

The Value of NOTCH2NLC Gene Detection and Skin Biopsy in the Diagnosis of Neuronal Intranuclear Inclusion Disease

 

The clinical manifestations of neuronal intranuclear inclusion disease (NIID) are heterogeneous, and the premortem diagnosis is mainly based on skin biopsy findings. Abnormal GGC repeat expansions in NOTCH2NLC was recently identified in familial and sporadic NIID. The comparison of diagnostic value between abnormal GGC repeat expansions of NOTCH2NLC and skin biopsy has not been conducted yet.
In this study, skin biopsy was performed in 10 suspected adult NIID patients with clinical and imaging manifestations, and GGC repeat size in NOTCH2NLC was also screened by repeat primed-PCR and GC-rich PCR. We found that five cases had ubiquitin-immunolabelling intranuclear inclusion bodies by skin biopsy, and all of them were identified with abnormal GGC repeat expansions in NOTCH2NLC, among whom four patients showed typical linear hyperintensity at corticomedullary junction on DWI.
Five (5/10) NIID patients were diagnosed by combination of NOTCH2NLC gene detection, skin biopsy or combination of NOTCH2NLC, and typical MRI findings. The diagnostic performance of NOTCH2NLC gene detection was highly consistent with that of skin biopsy (Kappa = 1). The unexplained headache was firstly reported as a new early phenotype of NIID. These findings indicate that NOTCH2NLC gene detection is needed to be a supplement in the diagnose flow of NIID and also may be used as an alternative method to skin biopsy especially in Asian population.
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EpCAM Antigen

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Human epithelial specific antigen(ESA)ELISA Kit

GA-E1696HM-48T 48T
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Human epithelial specific antigen(ESA)ELISA Kit

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Anti-Ep-CAM/Epithelial Specific Antigen antibody

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Human epithelial specific antigen,ESA ELISA Kit

201-12-1680 96 tests
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human epithelial specific antigen(ESA)ELISA Kit

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Human epithelial specific antigen,ESA ELISA Kit

CN-04610H1 96T
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Human epithelial specific antigen,ESA ELISA Kit

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Recombinant Epithelial Cell Adhesion Molecule (EPCAM)

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  • EUR 4132.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Chicken Epithelial Cell Adhesion Molecule expressed in: E.coli

Recombinant Epithelial Cell Adhesion Molecule (EPCAM)

4-RPB283Hu01
  • EUR 440.48
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  • EUR 3292.00
  • 100 ug
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  • 1 mg
  • 200 ug
  • 500 ug
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  • 5 mg
Description: Recombinant Human Epithelial Cell Adhesion Molecule expressed in: E.coli

Recombinant Epithelial Cell Adhesion Molecule (EPCAM)

4-RPB283Po01
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  • 100 ug
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  • 500 ug
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  • 5 mg
Description: Recombinant Pig Epithelial Cell Adhesion Molecule expressed in: E.coli

Human Epithelial cell adhesion molecule (EPCAM)

1-CSB-EP007717HU
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Description: Recombinant Human Epithelial cell adhesion molecule(EPCAM),partial expressed in E.coli

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

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Epithelial Cell Adhesion Molecule (EpCAM) Antibody

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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

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Epithelial Cell Adhesion Molecule (EpCAM) Antibody

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EUR 391

Epithelial Cell Adhesion Molecule (EpCAM) Antibody

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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

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Epithelial Cell Adhesion Molecule (EpCAM) Antibody

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EUR 523

Epithelial Cell Adhesion Molecule (EpCAM) Antibody

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EUR 286

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

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EUR 467

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx242428
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx242433
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx214622
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx232799-100ug 100 ug
EUR 509

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx176308
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  • EUR 133.00
  • EUR 1149.00
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx172278
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  • 1 mg
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx224065-100ug 100 ug
EUR 411

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx331190-100ul 100 ul
EUR 425

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx327226
  • EUR 314.00
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  • 100 ug
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx324346
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  • 100 ug
  • 50 ug

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC042041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF405S conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC042041-500 500uL
EUR 545
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (HRP)

20-abx335604
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (FITC)

20-abx335605
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (Biotin)

20-abx335606
  • EUR 411.00
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  • 100 ug
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Human Epithelial Cell Adhesion Molecule (EPCAM) Protein

20-abx652155
  • EUR 620.00
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  • EUR 1859.00
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC432041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF543 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC432041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF543 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC472041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF647 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC472041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF647 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCAP2041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCAP2041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC802041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF680 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC802041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF680 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC812041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF680R conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC812041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF680R conjugate, Concentration: 0.1mg/mL

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (PE)

abx140492-100tests 100 tests
EUR 481

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (FITC)

abx140496-100tests 100 tests
EUR 425

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC682041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF568 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC682041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF568 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC702041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF770 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC702041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF770 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC882041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF488A conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC882041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF488A conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC612041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF660R conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC612041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF660R conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC942041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF594 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC942041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF594 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCA2041-250 250uL
EUR 394
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), APC conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNUB2041-100 100uL
EUR 264
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Concentration: 0.2mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNUB2041-50 50uL
EUR 405
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), 1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNUB2041-500 500uL
EUR 513
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Concentration: 0.2mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCH2041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCH2041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC052041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF405M conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC052041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF405M conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCP2041-250 250uL
EUR 394
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), PerCP conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCR2041-250 250uL
EUR 394
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Pig Epithelial Cell Adhesion Molecule (EPCAM) Protein

20-abx167541
  • EUR 759.00
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  • EUR 2388.00
  • EUR 913.00
  • EUR 537.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Chicken Epithelial Cell Adhesion Molecule (EPCAM) Protein

20-abx168032
  • EUR 732.00
  • EUR 286.00
  • EUR 2305.00
  • EUR 885.00
  • EUR 523.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (FITC)

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  • EUR 523.00
  • EUR 606.00
  • EUR 300.00
  • EUR 940.00
  • EUR 384.00
  • 100 tests
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (APC)

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  • EUR 704.00
  • EUR 829.00
  • EUR 370.00
  • EUR 1330.00
  • EUR 495.00
  • 100 tests
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (PE)

20-abx270964
  • EUR 606.00
  • EUR 718.00
  • EUR 328.00
  • EUR 1135.00
  • EUR 439.00
  • 100 tests
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC402041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF640R conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC402041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF640R conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCB2041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Biotin conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCB2041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Biotin conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC552041-100 100uL
EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF555 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC552041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF555 conjugate, Concentration: 0.1mg/mL

Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

SEB283Hu-10x96wellstestplate 10x96-wells test plate
EUR 4502.43
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Epithelial Cell Adhesion Molecule (EPCAM) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

SEB283Hu-1x48wellstestplate 1x48-wells test plate
EUR 458.44
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Epithelial Cell Adhesion Molecule (EPCAM) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

SEB283Hu-1x96wellstestplate 1x96-wells test plate
EUR 612.05
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Epithelial Cell Adhesion Molecule (EPCAM) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

SEB283Hu-5x96wellstestplate 5x96-wells test plate
EUR 2454.23
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Epithelial Cell Adhesion Molecule (EPCAM) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

4-SEB283Hu
  • EUR 4553.00
  • EUR 2405.00
  • EUR 613.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Epithelial Cell Adhesion Molecule (EPCAM) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Epithelial cell adhesion molecule(EPCAM) ELISA kit

CSB-EL007717HU-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Epithelial cell adhesion molecule (EPCAM) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Epithelial cell adhesion molecule(EPCAM) ELISA kit

1-CSB-EL007717HU
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Epithelial cell adhesion molecule(EPCAM) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken)

4-PAB283Ga01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM)

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig)

4-PAB283Po01
  • EUR 267.00
  • EUR 2826.00
  • EUR 697.00
  • EUR 338.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM)

Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human)

4-MAB283Hu21
  • EUR 247.00
  • EUR 2516.00
  • EUR 626.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM)

EPCAM Epithelial Cell Adhesion Molecule Human Recombinant Protein

PROTP16422 Regular: 20ug
EUR 317
Description: EPCAM Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 267 amino acids (24-265 a.a.) and having a molecular mass of 30.1kDa.;EPCAM is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Human Epithelial Cell Adhesion Molecule, EPCAM ELISA Kit

DEIA244 5 plates
EUR 1344
Description: The human EPCAM ELISA kit is for the quantitative determination of human EPCAM.

Human EPCAM/ Epithelial cell adhesion molecule ELISA Kit

E0800Hu 1 Kit
EUR 571

Human Epithelial Cell Adhesion Molecule (EPCAM) CLIA Kit

20-abx492586
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Pig Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

abx361484-96tests 96 tests
EUR 825

Rabbit Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

abx363660-96tests 96 tests
EUR 825

Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

abx350740-96tests 96 tests
EUR 668

Chicken Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

abx356953-96tests 96 tests
EUR 825

Monkey Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

abx359768-96tests 96 tests
EUR 825

Cow Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

abx516210-96tests 96 tests
EUR 911

Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

abx516212-96tests 96 tests
EUR 668

Mouse Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

abx516213-96tests 96 tests
EUR 707

Rat Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

abx516215-96tests 96 tests
EUR 668

Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

20-abx151423
  • EUR 7112.00
  • EUR 3792.00
  • EUR 879.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Epithelial Cell Adhesion Molecule (EPCAM) CLIA Kit

abx196638-96tests 96 tests
EUR 825

Mouse Epithelial Cell Adhesion Molecule (EPCAM) CLIA Kit

abx196938-96tests 96 tests
EUR 825

Mouse Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit

abx254058-96tests 96 tests
EUR 707

Mouse EPCAM(Epithelial Cell Adhesion Molecule) ELISA Kit

EM1005 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.047 ng/ml

Chicken Epithelial cell adhesion molecule, EPCAM ELISA KIT

ELI-04242c 96 Tests
EUR 928

Human Epithelial cell adhesion molecule, EPCAM ELISA KIT

ELI-04243h 96 Tests
EUR 824

Bovine Epithelial cell adhesion molecule, EPCAM ELISA KIT

ELI-04246b 96 Tests
EUR 928

Mouse Epithelial cell adhesion molecule, Epcam ELISA KIT

ELI-04247m 96 Tests
EUR 865

Epithelial Membrane Antigen (MUC1) Antibody

20-abx121644
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Epithelial Membrane Antigen (MUC1) Antibody

20-abx123255
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul

Epithelial Membrane Antigen (MUC1) Antibody

20-abx133246
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Epithelial Membrane Antigen (MUC1) Antibody

abx025382-400ul 400 ul
EUR 523

Epithelial Membrane Antigen (MUC1) Antibody

abx025382-80l 80 µl
EUR 286

Epithelial Membrane Antigen (MUC1) Antibody

abx020564-1mg 1 mg
EUR 843

Epithelial Membrane Antigen (MUC1) Antibody

abx020565-1mg 1 mg
EUR 801

Epithelial Membrane Antigen (MUC1) Antibody

abx020566-1mg 1 mg
EUR 843

Epithelial Membrane Antigen (MUC1) Antibody

abx020567-1mg 1 mg
EUR 843

Epithelial Membrane Antigen (MUC1) Antibody

abx020569-1mg 1 mg
EUR 801

Epithelial Membrane Antigen (MUC1) Antibody

abx020571-1mg 1 mg
EUR 801

Epithelial Membrane Antigen (EMA) Antibody

abx022470-02mg 0.2 mg
EUR 940

Epithelial Membrane Antigen (MUC1) Antibody

abx023797-1mg 1 mg
EUR 843

Epithelial Membrane Antigen (MUC1) Antibody

abx235427-100ug 100 ug
EUR 551

Epithelial Membrane Antigen (MUC1) Antibody

abx235428-100ug 100 ug
EUR 551

Prostate Specific Antigen Std Grade Antigen

VAng-Cr3891-1mg 1 mg
EUR 504
Description: Prostate Specific Antigen Std Grade Antigen, Host/Source: Human Seminal Fluid. The purity is detected by salt precipitation.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), APC

4-PAB283Ga01-APC
  • EUR 351.00
  • EUR 3365.00
  • EUR 935.00
  • EUR 449.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with APC.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), Biotinylated

4-PAB283Ga01-Biotin
  • EUR 316.00
  • EUR 2526.00
  • EUR 744.00
  • EUR 387.00
  • EUR 221.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Biotin.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), Cy3

4-PAB283Ga01-Cy3
  • EUR 427.00
  • EUR 4445.00
  • EUR 1205.00
  • EUR 557.00
  • EUR 254.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Cy3.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), FITC

4-PAB283Ga01-FITC
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with FITC.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), HRP

4-PAB283Ga01-HRP
  • EUR 321.00
  • EUR 2933.00
  • EUR 827.00
  • EUR 405.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with HRP.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), PE

4-PAB283Ga01-PE
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with PE.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), APC

4-PAB283Po01-APC
  • EUR 376.00
  • EUR 3707.00
  • EUR 1020.00
  • EUR 483.00
  • EUR 232.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with APC.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), Biotinylated

4-PAB283Po01-Biotin
  • EUR 334.00
  • EUR 2776.00
  • EUR 806.00
  • EUR 412.00
  • EUR 228.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Biotin.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), Cy3

4-PAB283Po01-Cy3
  • EUR 459.00
  • EUR 4901.00
  • EUR 1319.00
  • EUR 602.00
  • EUR 267.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Cy3.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), FITC

4-PAB283Po01-FITC
  • EUR 320.00
  • EUR 2985.00
  • EUR 836.00
  • EUR 406.00
  • EUR 205.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with FITC.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), HRP

4-PAB283Po01-HRP
  • EUR 342.00
  • EUR 3229.00
  • EUR 901.00
  • EUR 435.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with HRP.

Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), PE

4-PAB283Po01-PE
  • EUR 320.00
  • EUR 2985.00
  • EUR 836.00
  • EUR 406.00
  • EUR 205.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with PE.

Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), APC

4-MAB283Hu21-APC
  • EUR 346.00
  • EUR 3284.00
  • EUR 914.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with APC.

Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), Biotinylated

4-MAB283Hu21-Biotin
  • EUR 312.00
  • EUR 2466.00
  • EUR 729.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Biotin.

Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), Cy3

4-MAB283Hu21-Cy3
  • EUR 420.00
  • EUR 4337.00
  • EUR 1178.00
  • EUR 546.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Cy3.

Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), FITC

4-MAB283Hu21-FITC
  • EUR 297.00
  • EUR 2647.00
  • EUR 751.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with FITC.

Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), HRP

4-MAB283Hu21-HRP
  • EUR 316.00
  • EUR 2862.00
  • EUR 809.00
  • EUR 398.00
  • EUR 207.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with HRP.

Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), PE

4-MAB283Hu21-PE
  • EUR 297.00
  • EUR 2647.00
  • EUR 751.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with PE.

ELISA kit for Mouse EPCAM (Epithelial Cell Adhesion Molecule)

E-EL-M0470 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse EPCAM (Epithelial Cell Adhesion Molecule) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Mouse EPCAM (Epithelial Cell Adhesion Molecule)

E-CL-M0286 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Mouse EPCAM (Epithelial Cell Adhesion Molecule) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human Epithelial cell adhesion molecule (EPCAM)

KTE62402-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Human Epithelial cell adhesion molecule (EPCAM) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Epithelial cell adhesion molecule (EPCAM)

KTE62402-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Human Epithelial cell adhesion molecule (EPCAM) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Epithelial cell adhesion molecule (EPCAM)

KTE62402-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Human Epithelial cell adhesion molecule (EPCAM) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human EPCAM (Epithelial Cell Adhesion Molecule)

ELK1968 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Epithelial Cell Adhesion Molecule from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Mouse Anti-Human Ep-CAM/Epithelial Specific Antigen monoclonal antibody, clone JID678

CABT-L2933-100uL500uL 100 uL, 500 uL
EUR 502

Prostate-specific Antigen Antibody

33477-100ul 100ul
EUR 252

Prostate-specific Antigen Antibody

33477-50ul 50ul
EUR 187

digIS: towards detecting distant and putative novel insertion sequence elements in prokaryotic genomes

Background: The insertion sequence elements (IS elements) represent the smallest and the most abundant mobile elements in prokaryotic genomes. It has been shown that they play a significant role in genome organization and evolution. To better understand their function in the host genome, it is desirable to have an effective detection and annotation tool.

This need becomes even more crucial when considering rapid-growing genomic and metagenomic data. The existing tools for IS elements detection and annotation are usually based on comparing sequence similarity with a database of known IS families. Thus, they have limited ability to discover distant and putative novel IS elements.

Results: In this paper, we present digIS, a software tool based on profile hidden Markov models assembled from catalytic domains of transposases. It shows a very good performance in detecting known IS elements when tested on datasets with manually curated annotation. The main contribution of digIS is in its ability to detect distant and putative novel IS elements while maintaining a moderate level of false positives. In this category it outperforms existing tools, especially when tested on large datasets of archaeal and bacterial genomes.

Conclusion: We provide digIS, a software tool using a novel approach based on manually curated profile hidden Markov models, which is able to detect distant and putative novel IS elements. Although digIS can find known IS elements as well, we expect it to be used primarily by scientists interested in finding novel IS elements.

Gene Expression Changes in a Model Neuron Cell Line Exposed to Autoantibodies from Patients with Traumatic Brain Injury and/or Type 2 Diabetes

Traumatic brain injury and adult type 2 diabetes mellitus are each associated with the late occurrence of accelerated cognitive decline and Parkinson’s disease through unknown mechanisms. Previously, we reported increased circulating agonist autoantibodies targeting the 5-hydroxytryptamine 2A receptor in plasma from subsets of Parkinson’s disease, dementia, and diabetic patients suffering with microvascular complications.
Here, we use a model neuron, mouse neuroblastoma (N2A) cell line, to test messenger RNA expression changes following brief exposure to traumatic brain injury and/or type 2 diabetes mellitus plasma harboring agonist 5-hydroxytryptamine 2A receptor autoantibodies.
We now report involvement of the mitochondrial dysfunction pathway and Parkinson’s disease pathways in autoantibody-induced gene expression changes occurring in neuroblastoma cells. Functional gene categories upregulated significantly included cell death, cytoskeleton-microtubule function, actin polymerization or depolymerization, regulation of cell oxidative stress, mitochondrial function, immune function, protein metabolism, and vesicle function.
Gene categories significantly downregulated included microtubule function, cell adhesion, neurotransmitter release, dopamine metabolism synaptic plasticity, maintenance of neuronal differentiation, mitochondrial function, and cell signaling.
Taken together, these results suggest that agonist 5-hydroxytryptamine receptor autoantibodies (which increase in Parkinson’s disease and other forms of neurodegeneration) mediate a coordinating program of gene expression changes in a model neuron which predispose to neuro-apoptosis and are linked to human neurodegenerative diseases pathways.

Novel Alzheimer’s disease risk variants identified based on whole-genome sequencing of APOE ε4 carriers

Alzheimer’s disease (AD) is a progressive neurodegenerative disease associated with a complex genetic etiology. Besides the apolipoprotein E ε4 (APOE ε4) allele, a few dozen other genetic loci associated with AD have been identified through genome-wide association studies (GWAS) conducted mainly in individuals of European ancestry.
Recently, several GWAS performed in other ethnic groups have shown the importance of replicating studies that identify previously established risk loci and searching for novel risk loci. APOE-stratified GWAS have yielded novel AD risk loci that might be masked by, or be dependent on, APOE alleles.
We performed whole-genome sequencing (WGS) on DNA from blood samples of 331 AD patients and 169 elderly controls of Korean ethnicity who were APOE ε4 carriers. Based on WGS data, we designed a customized AD chip (cAD chip) for further analysis on an independent set of 543 AD patients and 894 elderly controls of the same ethnicity, regardless of their APOE ε4 allele status.
Combined analysis of WGS and cAD chip data revealed that SNPs rs1890078 (P = 6.64E-07) and rs12594991 (P = 2.03E-07) in SORCS1 and CHD2 genes, respectively, are novel genetic variants among APOE ε4 carriers in the Korean population.
In addition, nine possible novel variants that were rare in individuals of European ancestry but common in East Asia were identified. This study demonstrates that APOE-stratified analysis is important for understanding the genetic background of AD in different populations.

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